Dehydroepiandrosterone (DHEA) modulates GHRH, somatostatin and angiotensin II action at the pituitary level.

Steroid modulation of angiotensin II action in the rat anterior pituitary gland.

OBJECTIVES The present study was designed to test whether various steroid hormones modulate differently angiotensin II (AngII) action in the anterior pituitary in males and females. MATERIAL AND METHODS Adult female and male rats were treated with one of the following substances: oil (control), pregnenolone sulfate (PREG-S), 17beta-estradiol benzoate (E2,) progesterone (P), or dehydroepiandro...

ACTH Adrenocorticotropic hormone CRF/CRH Corticotrophin releasing factor/hormone DALY Disability-adjusted life years DHEA Dehydroepiandrosterone DHEAS Dehydroepiandrosterone sulfate DNA Deoxyribose nucleic acid FSH Follicle stimulating hormone GH Growth hormone GHRH Growth hormone releasing hormone GnRH Gonadotropin releasing hormone HPA Hypothalamo–pituitary–adrenal axis

Marked attenuation of production of collagen type I from cardiac fibroblasts by dehydroepiandrosterone.

Dehydroepiandrosterone (DHEA) is a type of adrenal steroid. The concentrations of DHEA and its sulfate (DHEA-S) in serum reach a peak between the ages of 25 and 30 yr and thereafter decline steadily. It was reported that DHEA-S concentration in humans is inversely related to death from cardiovascular diseases. In this study, we examined the effects of DHEA on regulation of collagen mRNA and col...

Growth hormone (GH)-releasing hormone (GHRH) and the GH secretagogue (GHS), L692,585, differentially modulate rat pituitary GHS receptor and GHRH receptor messenger ribonucleic acid levels.

The ability of synthetic GH secretagogues (GHSs) to elicit a maximal release of GH in vivo is dependent on an intact GH-releasing hormone (GHRH) signaling system. The role of GHRH in GHS-induced GH release has been attributed primarily to the ability of GHS to release GHRH from hypothalamic neurons. However, GHS also releases GH directly at the pituitary level. Several lines of evidence suggest...

Dehydroepiandrosterone treatment attenuates oestrogen-induced pituitary hyperplasia.

The physiological importance of and therapeutic interest in dehydroepiandrosterone (DHEA) has been predominantly in relation to its action as an inhibitor of the promotion and progression of several kinds of tumours, including those of breast, prostate, lung, colon, liver and skin tissues. The aim of the present study was to determine the role of DHEA in diethylstilboestrol (DES)-induced pituit...